FACTS ABOUT NAD+ AND ITS ROLE IN MITOCHONDRIAL FUNCTION REVEALED

Upcoming, we handled cells with diverse concentrations of NAD+. When included for 24 h at 80 µM in HeLa and 400 µM in U2OS cells, NAD+ impaired the incorporation of EdU (Fig. 2a and Prolonged Details Fig. 1k,l). In addition, sixteen µM of NAD+ was ample to cut back fork pace by ~40% in HeLa cells without the need of affecting the entire